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How to get fromWilmington to St. Louisby train, plane, bus (Greyhound), train (Amtrak), car, or subway

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There are 10 ways to get from Wilmington to St. Louis by train, plane, bus (Greyhound), train (Amtrak), car, or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Philadelphia International Airport, fly

    best
    1. Take the train from Wilmington to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)plane plane PHL - STL
    4h 58m
    $162–1,348

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Wilmington Bus Station to Philadelphia Bus Stationbus bus Greyhound US0355 / ...
    2. Take the bus from Philadelphia Bus Station to St Louis Bus Stationbus bus Greyhound US0421
    22h 35m
    $134–268

  3. Train via Washington (Amtrak)

    1. Take the train from Wilmington to Washington Union Stationtrain train
    2. Take the train from Rockville Amtrak to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    26h 23m
    $342–1,304

  4. Drive 862.7 mi

    1. Drive from Wilmington to St. Louiscar car 862.7 mi
    15h 9m
    $158–228

  5. Train to Baltimore-Washington International Airport, fly

    1. Take the train from Wilmington to BWI Thurgood Marshalltrain train
    2. Fly from Baltimore-Washington International Airport (BWI) to Lambert–St. Louis International Airport (STL)plane plane BWI - STL
    5h 3m
    $151–1,239

  6. Train to Ronald Reagan Washington National Airport, fly

    1. Take the train from Wilmington to Washington Union Stationtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Lambert–St. Louis International Airport (STL)plane plane DCA - STL
    5h 53m
    $192–1,001

  7. Train to Newark Liberty International Airport, fly

    1. Take the train from Wilmington to Newark Liberty International Airporttrain train
    2. Fly from Newark Liberty International Airport (EWR) to Lambert–St. Louis International Airport (STL)plane plane EWR - STL
    5h 52m
    $406–871

  8. Train, subway to Washington Dulles International Airport, fly

    1. Take the train from Wilmington to Washington Union Stationtrain train
    2. Take the subway from Farragut West, Blue/Orange/Silver Line Track 2 Platform to Washington Dulles International Airport, Silver Line Center Platformsubway subway
    3. Fly from Washington Dulles International Airport (IAD) to Lambert–St. Louis International Airport (STL)plane plane IAD - STL
    6h 36m
    $212–1,620

  9. Train to Laguardia Airport, fly

    1. Take the train from Wilmington to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Laguardia Airport (LGA) to Lambert–St. Louis International Airport (STL)plane plane LGA - STL
    7h 12m
    $178–1,077

  10. Train (Amtrak)

    1. Take the train from Wilmington to Chicago Union Stationtrain train Cardinal
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    32h 26m
    $406–860

Wilmington to St. Louis by bus (Greyhound)

Calendar42Weekly Buses
Duration22h 35mAverage Duration
Ticket$134Cheapest Price
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Questions & Answers

Map of how to get from Wilmington to St. Louis.ExpandLaunch map view
  • Distance: 858.6 mi
  • Duration: 4h 58m

What companies run services between Wilmington, DE, USA and St. Louis, MO, USA?

You can take a bus from Wilmington Bus Station to St Louis Bus Station via Philadelphia Bus Station in around 22h 35m. Alternatively, you can take a train from Wilmington to St. Louis via Washington Union Station, Union Station, Red Line Center Platform, Rockville, Red Line Center Platform, Rockville Amtrak, and Chicago Union Station in around 26h 23m.

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