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How to get fromWilmington to St. Louisby plane, bus (Greyhound, Flixbus, Amtrak), car, taxi, or bus (Greyhound, Flixbus)

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There are 6 ways to get from Wilmington to St. Louis by plane, bus (Greyhound, Flixbus, Amtrak), car, taxi, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Wilmington International Airport

    best
    1. Fly from Wilmington International Airport (ILM) to Lambert–St. Louis International Airport (STL)plane plane ILM - STL
    5h 10m
    $127–570

  2. Bus via Carbondale

    1. Take the bus from Wilmington Cape Fear Public Transit to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Carbondale Intermodal Stationbus bus
    4. Take the bus from Carbondale Intermodal Station to St Louis Bus Stationbus bus
    25h 16m
    $156–312

  3. Drive 881.9 mi

    1. Drive from Wilmington to St. Louiscar car 881.9 mi
    16h 20m
    $161–233

  4. Taxi to Albert J. Ellis Airport, fly

    1. Take the taxi from Wilmington to Albert J. Ellis Airport (OAJ)taxi taxi
    2. Fly from Albert J. Ellis Airport (OAJ) to Lambert–St. Louis International Airport (STL)plane plane OAJ - STL
    6h 15m
    $245–759

  5. Bus

    1. Take the bus from Wilmington Cape Fear Public Transit to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    25h 40m
    $156–317

  6. Bus #2

    1. Take the bus from Wilmington Cape Fear Public Transit to Myrtle Beach Bus Stationbus bus
    2. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    25h 43m
    $152–304

Wilmington to St. Louis by bus

Calendar10Weekly Buses
Duration25h 16mAverage Duration
Ticket$156Cheapest Price
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Questions & Answers

Map of how to get from Wilmington to St. Louis.ExpandLaunch map view
  • Distance: 775.5 mi
  • Duration: 5h 10m

What companies run services between Wilmington, NC, USA and St. Louis, MO, USA?

American Airlines, Delta, and United Airlines fly from Wilmington International Airport (ILM) to Lambert–St. Louis International Airport (STL) every 2 hours. Alternatively, you can take a bus from Market St EB at 6th St to St Louis Bus Station via Wilmington Cape Fear Public Transit, Charlotte Bus Station, Atlanta Bus Station, and Carbondale Intermodal Station in around 25h 16m.

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