There are 8 ways to get from Winona to Louisville by taxi, plane, train, bus, bus (Amtrak), car, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Taxi to La Crosse, fly
best- Take the taxi from Winona to La-Crosse-Airport-LSEtaxi
- Fly from La Crosse (LSE) to Louisville International Airport (SDF)plane LSE - SDF
5h 54m$157–631Drive 597.8 mi
cheapest- Drive from Winona to Louisvillecar 597.8 mi
10h 2m$110–158Train, bus (Amtrak)
- Take the train from Winona to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Indianapolistrain
- Take the bus from Indianapolis Union Station to Louisville, KYbus
15h 3m$158–351Bus via Chicago
- Take the bus from Winona St. University to Madisonbus
- Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus
- Take the bus from Chicago Union Station to Louisville, KYbus
15h 57m$121–181Drive to Chippewa Valley Regional Airport, fly
- Drive from Winona to Eau-Claire-Airport-EAUcar
- Fly from Chippewa Valley Regional Airport (EAU) to Louisville International Airport (SDF)plane EAU - SDF
7h 17m$114–622Train to Minneapolis–Saint Paul International Airport, fly
- Take the train from Winona to St. Paul-Minneapolistrain
- Fly from Minneapolis–Saint Paul International Airport (MSP) to Louisville International Airport (SDF)plane MSP - SDF
7h 5m$152–768Bus to Rochester, fly
- Take the bus from Winona St. University to Rochesterbus
- Fly from Rochester (RST) to Louisville International Airport (SDF)plane RST - SDF
9h 29m$124–674Bus
- Take the bus from Winona St. University to Madisonbus
- Take the bus from Madison to Cincinnatibus
- Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus
17h 17m$115–219
Winona to Louisville by train and bus (Amtrak)
Questions & Answers
The cheapest way to get from Winona to Louisville is to drive which costs $100 - $160 and takes 10h 2m.
The fastest way to get from Winona to Louisville is to taxi and fly which takes 5h 54m and costs $150 - $650.
No, there is no direct bus from Winona to Louisville. However, there are services departing from Winona St. University and arriving at Louisville, KY via 250 N. Lake St - Madison UW Campus and Chicago Union Station. The journey, including transfers, takes approximately 15h 57m.
The distance between Winona and Louisville is 524 miles. The road distance is 601.2 miles.
The best way to get from Winona to Louisville without a car is to train and bus which takes 15h 3m and costs $150 - $360.
It takes approximately 5h 54m to get from Winona to Louisville, including transfers.
Winona to Louisville bus services, operated by Jefferson Lines, depart from Winona St. University station.
Winona to Louisville bus services, operated by Jefferson Lines, arrive at Madison station.
Louisville is 1h ahead of Winona. It is currently 2:35 AM in Winona and 3:35 AM in Louisville.
Yes, the driving distance between Winona to Louisville is 601 miles. It takes approximately 10h 2m to drive from Winona to Louisville.
What companies run services between Winona, MN, USA and Louisville, KY, USA?
You can take a bus from Winona St. University to Louisville, KY via Madison, 250 N. Lake St - Madison UW Campus, W Jackson Blvd, after S Clinton St, and Chicago Union Station in around 15h 57m.
- Website
- delta.com
Flights from Minneapolis–Saint Paul International Airport to Louisville International Airport
- Ave. Duration
- 1h 59m
- When
- Every day
- Estimated price
- $120–700
Flights from Rochester to Louisville International Airport via Minneapolis–Saint Paul International Airport
- Ave. Duration
- 5h 44m
- When
- Every day
- Estimated price
- $110–600
- Website
- united.com
Flights from La Crosse to Louisville International Airport via Chicago O'Hare
- Ave. Duration
- 7h 26m
- When
- Every day
- Estimated price
- $90–550
Flights from Chippewa Valley Regional Airport to Louisville International Airport via Chicago O'Hare
- Ave. Duration
- 5h 41m
- When
- Every day
- Estimated price
- $100–600
Flights from Minneapolis–Saint Paul International Airport to Louisville International Airport via Chicago O'Hare
- Ave. Duration
- 4h 11m
- When
- Every day
- Estimated price
- $120–700
Flights from Rochester to Louisville International Airport via Chicago O'Hare
- Ave. Duration
- 5h 8m
- When
- Sunday
- Estimated price
- $100–600
- Website
- southwest.com
Flights from Minneapolis–Saint Paul International Airport to Louisville International Airport via Chicago Midway
- Ave. Duration
- 3h 42m
- When
- Every day
- Estimated price
- $120–700
Flights from Minneapolis–Saint Paul International Airport to Louisville International Airport via Nashville
- Ave. Duration
- 4h
- When
- Tuesday and Wednesday
- Estimated price
- $150–800
- Website
- aa.com
Flights from La Crosse to Louisville International Airport via Chicago O'Hare
- Ave. Duration
- 5h 9m
- When
- Every day
- Estimated price
- $90–550
Flights from Rochester to Louisville International Airport via Chicago O'Hare
- Ave. Duration
- 6h 18m
- When
- Every day
- Estimated price
- $100–600
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Winona to Chicago Union Station
- Ave. Duration
- 5h 44m
- Frequency
- 3 times a day
- Estimated price
- $85–190
- Website
- Amtrak
Train from Chicago Union Station to Indianapolis
- Ave. Duration
- 4h 54m
- Frequency
- 3 times a week
- Estimated price
- $50–120
- Website
- Amtrak
Train from Winona to St. Paul-Minneapolis
- Ave. Duration
- 2h 16m
- Frequency
- 3 times a day
- Estimated price
- $28–65
- Website
- Amtrak
Rome2Rio's guide to Amtrak Thruway
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Indianapolis Union Station to Louisville, KY
- Ave. Duration
- 2h 25m
- Frequency
- Twice daily
- Estimated price
- $22–45
- Website
- Amtrak
- Adult
- $22–45
Bus from Chicago Union Station to Louisville, KY
- Ave. Duration
- 7h
- Frequency
- Twice daily
- Estimated price
- $50–60
- Website
- Amtrak
- Adult
- $50–60
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Winona St. University to Madison
- Ave. Duration
- 3h 20m
- Frequency
- Once daily
- Estimated price
- $40–65
- Book at
- Jefferson Lines
- Adult
- $40–65
Bus from Winona St. University to Rochester
- Ave. Duration
- 55 min
- Frequency
- Once daily
- Estimated price
- $22–35
- Book at
- Jefferson Lines
- Adult
- $22–35
Bus from Winona St. University to Madison
- Ave. Duration
- 3h 20m
- Frequency
- Once daily
- Estimated price
- $40–65
- Book at
- Jefferson Lines
- Adult
- $40–65
- Phone
- +1 (866) 912 - 6224
- [email protected]
- Website
- Rockland Coaches
Bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton St
- Ave. Duration
- 4h
- Frequency
- Hourly
- Estimated price
- $26–60
- Schedules at
- Rockland Coaches
- Adult
- $26–60
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Madison to Cincinnati
- Ave. Duration
- 9h 30m
- Frequency
- 6 times a week
- Estimated price
- $60–110
- Schedules at
- Flixbus USA
- Phone
- +1 888-378-3823
- [email protected]
- Website
- Barons Bus
Bus from Cincinnati - Downtown to Louisville, KY Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Once daily
- Estimated price
- $9–45
- Website
- Barons Bus
- Ave. Duration
- 31 min
- Estimated price
- $65–80
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
More Questions & Answers
Book your Winona to Louisville bus tickets online with Omio.
There are 596+ hotels available in Louisville.













