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How to get fromWinston-Salem to Buffaloby plane, bus, car, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Winston-Salem to Buffalo by plane, bus, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Piedmont Triad International Airport

    best
    1. Fly from Piedmont Triad International Airport (GSO) to Buffalo Niagara International Airport (BUF)plane plane GSO - BUF
    6h 15m
    $130–724

  2. Bus

    cheapest
    1. Take the bus from Winston Salem(Trans Center) to Charleston, WVbus bus
    2. Take the bus from Charleston, WV to Cleveland, OHbus bus
    3. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    15h 15m
    $65–189

  3. Drive  600.3 mi

    1. Drive from Winston-Salem to Buffalocar car 600.3 mi
    10h 27m
    $110–159

  4. Bus to Charlotte Douglas International Airport, fly

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Buffalo Niagara International Airport (BUF)plane plane CLT - BUF
    5h 57m
    $117–629

  5. Bus to Raleigh-Durham International Airport, fly

    1. Take the bus from Winston Salem(Trans Center) to Durhambus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Buffalo Niagara International Airport (BUF)plane plane RDU - BUF
    6h 50m
    $139–453

  6. Bus via Akron

    1. Take the bus from Winston Salem(Trans Center) to Charleston, WVbus bus
    2. Take the bus from Charleston to Akronbus bus
    3. Take the bus from Akron to Buffalobus bus
    15h 25m
    $66–189

  7. Bus via Washington

    1. Take the bus from Winston Salem(Trans Center) to Washington Union Stationbus bus
    2. Take the bus from Washington Union Station to Ithacabus bus
    3. Take the bus from Ithaca to Buffalobus bus
    23h 45m
    $157–272

Winston-Salem to Buffalo by bus

Calendar7Weekly Buses
Duration15h 15mAverage Duration
Ticket$65Cheapest Price
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Questions & Answers

Map of how to get from Winston-Salem to Buffalo.ExpandLaunch map view
  • Distance: 512.1 mi
  • Duration: 6h 15m

What companies run services between Winston-Salem, NC, USA and Buffalo, NY, USA?

United Airlines, Delta, and American Airlines fly from Piedmont Triad International Airport (GSO) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a bus from Winston Salem(Trans Center) to Buffalo, NY via Charleston, WV and Cleveland, OH in around 15h 15m.

Airlines
Bus operators

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