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How to get fromWinston-Salem to Buffaloby plane, bus, train, car, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Winston-Salem to Buffalo by plane, bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Piedmont Triad International Airport to Buffalo Niagara International Airport

    best
    1. Fly from Piedmont Triad International Airport (GSO) to Buffalo Niagara International Airport (BUF)plane plane GSO - BUF
    6h 44m
    $124–650

  2. Bus

    cheapest
    1. Take the bus from Winston Salem to Charlestonbus bus
    2. Take the bus from Charleston to Clevelandbus bus
    3. Take the bus from Cleveland to Buffalobus bus
    16h 25m
    $69–192

  3. Bus, train

    1. Take the bus from Winston Salem(Trans Center) to Greensboro Bus Stopbus bus
    2. Take the train from Greensboro to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    22h 28m
    $525–808

  4. Drive  600.3 mi

    1. Drive from Winston-Salem to Buffalocar car 600.3 mi
    10h 27m
    $107–154

  5. Bus to Charlotte Douglas International Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Buffalo Niagara International Airport (BUF)plane plane CLT - BUF
    6h 2m
    $123–655

  6. Bus to Charlotte Douglas International Airport, fly to Rochester, bus

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Rochester (ROC)plane plane CLT - ROC
    3. Take the bus from Rochester Bus Stop to Buffalobus bus
    7h 29m
    $178–869

  7. Bus via Washington

    1. Take the bus from Winston Salem(Trans Center) to Washington Union Stationbus bus
    2. Take the bus from Washington Union Station to Pittsburgh Intermodal Stationbus bus
    3. Take the bus from Pittsburgh, Pa to Buffalo, Nybus bus 510
    24h 5m
    $147–353

Winston-Salem to Buffalo by bus

Calendar7Weekly Buses
Duration16h 25mAverage Duration
Ticket$69Cheapest Price
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Comparing Your Travel Options

Map of how to get from Winston-Salem to Buffalo.ExpandLaunch map view
  • Distance: 509.4 mi
  • Duration: 6h 44m

What companies run services between Winston-Salem, NC, USA and Buffalo, NY, USA?

American Airlines, United Airlines, and Delta fly from Piedmont Triad International Airport (GSO) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a bus from Baptist Hospital to Buffalo via Winston Salem, Charleston, and Cleveland in around 16h 25m.

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