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How to get fromWinston-Salem to Des Moinesby plane, bus (Greyhound), bus, train, car, or bus (Flixbus, Greyhound)

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There are 9 ways to get from Winston-Salem to Des Moines by plane, bus (Greyhound), bus, train, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Piedmont Triad International Airport

    best
    1. Fly from Piedmont Triad International Airport (GSO) to Des Moines (DSM)plane plane GSO - DSM
    6h 20m
    $136–596

  2. Bus to Charlotte Douglas International Airport, fly

    cheapest
    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Des Moines (DSM)plane plane CLT - DSM
    5h 48m
    $116–489

  3. Bus

    1. Take the bus from Winston Salem to Columbusbus bus
    2. Take the bus from Columbus to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    26h 30m
    $152–262

  4. Bus, train

    1. Take the bus from Winston Salem(Trans Center) to Greensboro Bus Stopbus bus
    2. Take the train from Greensboro to Charlottesvilletrain train
    3. Take the train from Charlottesville to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    32h 18m
    $510–827

  5. Drive  976.6 mi

    1. Drive from Winston-Salem to Des Moinescar car 976.6 mi
    16h 57m
    $179–258

  6. Bus to Raleigh-Durham International Airport, fly

    1. Take the bus from Winston Salem(Trans Center) to Durhambus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Des Moines (DSM)plane plane RDU - DSM
    8h 49m
    $131–530

  7. Bus via Chicago

    1. Take the bus from Winston Salem to Columbusbus bus
    2. Take the bus from Columbus to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    26h 44m
    $154–270

  8. Train, bus

    1. Take the train from Greensboro to Carytrain train
    2. Take the train from Cary to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    37h 52m
    $650–1,110

  9. Bus, train via Galesburg

    1. Take the bus from Winston Salem(Trans Center) to Greensboro Bus Stopbus bus
    2. Take the train from Greensboro to Raleigh Union Stationtrain train
    3. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    5. Take the bus from Galesburg to Des Moinesbus bus
    38h 21m
    $715–1,222

Winston-Salem to Des Moines by bus

Calendar7Weekly Buses
Duration26h 30mAverage Duration
Ticket$152Cheapest Price
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Comparing Your Travel Options

Map of how to get from Winston-Salem to Des Moines.ExpandLaunch map view
  • Distance: 856.7 mi
  • Duration: 6h 20m

What companies run services between Winston-Salem, NC, USA and Des Moines, IA, USA?

United Airlines, Delta, and American Airlines fly from Piedmont Triad International Airport (GSO) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Baptist Hospital to Des Moines via Winston Salem, Columbus, and Indianapolis Union Station in around 26h 30m.

Airlines
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Bus operators

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