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How to get fromWinston-Salem to Des Moinesby plane, bus, train, or car

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There are 7 ways to get from Winston-Salem to Des Moines by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Piedmont Triad International Airport

    best
    1. Fly from Piedmont Triad International Airport (GSO) to Des Moines (DSM)plane plane GSO - DSM
    6h 13m
    $226–994

  2. Drive 976.6 mi

    cheapest
    1. Drive from Winston-Salem to Des Moinescar car 976.6 mi
    16h 57m
    $179–258

  3. Bus, train

    1. Take the bus from Winston Salem(Trans Center) to Ashlandbus bus
    2. Take the train from Ashland Amtrak Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    25h 11m
    $182–389

  4. Bus to Charlotte Douglas International Airport, fly

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Des Moines (DSM)plane plane CLT - DSM
    5h 43m
    $203–900

  5. Bus to Raleigh-Durham International Airport, fly

    1. Take the bus from Winston Salem(Trans Center) to Durhambus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Des Moines (DSM)plane plane RDU - DSM
    8h 29m
    $204–851

  6. Bus, train via Des Moines

    1. Take the bus from Winston Salem(Trans Center) to Ashlandbus bus
    2. Take the train from Ashland Amtrak Station to Indianapolistrain train
    3. Take the bus from Indianapolis to Des Moinesbus bus
    27h 21m

  7. Bus

    1. Take the bus from Winston Salem to Columbusbus bus
    2. Take the bus from Columbus to Indianapolisbus bus
    3. Take the bus from Indianapolis to Des Moinesbus bus
    28h 34m

Winston-Salem to Des Moines by bus and train

Calendar3Weekly Services
Duration25h 11mAverage Duration
Ticket$182Cheapest Price
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Questions & Answers

Map of how to get from Winston-Salem to Des Moines.ExpandLaunch map view
  • Distance: 856.7 mi
  • Duration: 6h 13m

What companies run services between Winston-Salem, NC, USA and Des Moines, IA, USA?

American Airlines, United Airlines, and two other airlines fly from Piedmont Triad International Airport (GSO) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Baptist Hospital to Des Moines via Winston Salem, Columbus, S Grant Ave & E Mound St, S High St & E Rich St, Columbus, Indianapolis, and Indianapolis in around 28h 34m.

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