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How to get fromWinston-Salem to Florenceby bus (Greyhound), bus, train, car, or plane

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There are 7 ways to get from Winston-Salem to Florence by bus (Greyhound), bus, train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Greyhound)

    best
    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    5h 55m
    $29–59

  2. Bus, train

    1. Take the bus from Winston Salem(Trans Center) to Greensboro Bus Stopbus bus
    2. Take the train from Greensboro to Selma Stationtrain train
    3. Take the train from Selma Station to Florence Stationtrain train
    7h 42m
    $79–173

  3. Drive 158.9 mi

    1. Drive from Winston-Salem to Florencecar car 158.9 mi
    3h 5m
    $29–42

  4. Fly from Piedmont Triad International Airport

    1. Fly from Piedmont Triad International Airport (GSO) to Florence Regional Airport (FLO)plane plane GSO - FLO
    4h 53m
    $78–416

  5. Bus via Raleigh (Greyhound)

    1. Take the bus from Winston Salem(Trans Center) to Raleigh Bus Stationbus bus Greyhound US0670 / ...
    2. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus Greyhound US0642S / ...
    6h 4m
    $38–74

  6. Bus, train via Fayetteville

    1. Take the bus from Winston-Salem to Fayettevillebus bus Winston-Salem to Fayetteville
    2. Take the train from Fayetteville Amtrak Station to Florence Stationtrain train Palmetto / ...
    6h 16m
    $48–96

  7. Bus to Charlotte Douglas International Airport, fly

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Florence Regional Airport (FLO)plane plane CLT - FLO
    4h 20m
    $65–371

Winston-Salem to Florence by bus (Greyhound)

Calendar7Weekly Buses
Duration5h 55mAverage Duration
Ticket$29Cheapest Price
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Questions & Answers

Map of how to get from Winston-Salem to Florence.ExpandLaunch map view
  • Distance: 204.1 mi
  • Duration: 5h 55m

What companies run services between Winston-Salem, NC, USA and Florence, SC, USA?

You can take a bus from Winston Salem(Trans Center) to Florence Bus Station via Charlotte Bus Station and Camden in around 5h 55m. Alternatively, American Airlines flies from Piedmont Triad International Airport (GSO) to Florence Regional Airport (FLO) once daily.

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