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How to get fromWinston-Salem to Indianapolisby plane, bus (Flixbus), bus, train, car, or bus (Greyhound)

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There are 7 ways to get from Winston-Salem to Indianapolis by plane, bus (Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Piedmont Triad International Airport

    best
    1. Fly from Piedmont Triad International Airport (GSO) to Indianapolis (IND)plane plane GSO - IND
    6h 31m
    $130–674

  2. Bus

    cheapest
    1. Take the bus from Winston Salem to Columbusbus bus Bsb 33
    2. Take the bus from Wilson & Ferrell Shell Station - Columbus to Indianapolis Union Stationbus bus Greyhound US0421
    15h 35m
    $69–137

  3. Bus via Columbus

    1. Take the bus from Winston Salem to Columbusbus bus Bsb 33
    2. Take the bus from Columbus to Indianapolisbus bus FlixBus 2511 / ...
    15h 14m
    $70–135

  4. Bus, train

    1. Take the bus from Winston Salem(Trans Center) to Greensboro Bus Stopbus bus
    2. Take the train from Greensboro to Charlottesvilletrain train
    3. Take the train from Charlottesville to Indianapolistrain train
    21h 28m
    $425–707

  5. Drive  511.4 mi

    1. Drive from Winston-Salem to Indianapoliscar car 511.4 mi
    9h 6m
    $94–135

  6. Bus to Charlotte Douglas International Airport, fly

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Indianapolis (IND)plane plane CLT - IND
    5h 47m
    $103–577

  7. Bus to Raleigh-Durham International Airport, fly

    1. Take the bus from Winston Salem(Trans Center) to Durhambus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Indianapolis (IND)plane plane RDU - IND
    7h 22m
    $179–398

Winston-Salem to Indianapolis by bus

Calendar7Weekly Buses
Duration15h 14mAverage Duration
Ticket$70Cheapest Price
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Comparing Your Travel Options

Map of how to get from Winston-Salem to Indianapolis.ExpandLaunch map view
  • Distance: 465.3 mi
  • Duration: 6h 31m

What companies run services between Winston-Salem, NC, USA and Indianapolis, IN, USA?

American Airlines, United Airlines, and Delta fly from Piedmont Triad International Airport (GSO) to Indianapolis (IND) hourly. Alternatively, you can take a bus from Baptist Hospital to Indianapolis via Winston Salem, Columbus, S Grant Ave & E Mound St, S High St & E Rich St, and Columbus in around 15h 14m.

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