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How to get fromWinston-Salem to Iowaby bus, plane, train, car, or bus (Flixbus, Greyhound)

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There are 8 ways to get from Winston-Salem to Iowa by bus, plane, train, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Charlotte Douglas International Airport, fly to Des Moines

    best
    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Des Moines (DSM)plane plane CLT - DSM
    5h 50m
    $117–503

  2. Bus to Charlotte Douglas International Airport, fly to Quad City International Airport

    cheapest
    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Quad City International Airport (MLI)plane plane CLT - MLI
    7h 7m
    $92–454

  3. Bus, train

    1. Take the bus from Winston Salem(Trans Center) to Ashlandbus bus
    2. Take the train from Ashland Amtrak Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    25h 16m
    $175–360

  4. Drive  976.6 mi

    1. Drive from Winston-Salem to Des Moinescar car 976.6 mi
    16h 57m
    $179–258

  5. Bus to Charlotte Douglas International Airport, fly to The Eastern Iowa Airport

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to The Eastern Iowa Airport (CID)plane plane CLT - CID
    5h 54m
    $135–512

  6. Fly Piedmont Triad International Airport to Quad City International Airport

    1. Fly from Piedmont Triad International Airport (GSO) to Quad City International Airport (MLI)plane plane GSO - MLI
    7h 33m
    $116–524

  7. Bus to Charlotte Douglas International Airport, fly to Omaha

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Omaha (OMA)plane plane CLT - OMA
    6h 8m
    $150–652

  8. Bus

    1. Take the bus from Winston Salem to Columbusbus bus
    2. Take the bus from Columbus to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    26h 50m
    $157–276

Charlotte Douglas International Airport (CLT) to Des Moines (DSM) flights

Calendar91Weekly Planes
Duration4hAverage Duration
Ticket$89Cheapest Price
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Questions & Answers

Map of how to get from Winston-Salem to Iowa.ExpandLaunch map view
  • Distance: 904.8 mi
  • Duration: 5h 50m

What companies run services between Winston-Salem, NC, USA and Iowa, USA?

Delta, American Airlines, and United Airlines fly from Piedmont Triad International Airport (GSO) to Quad City International Airport (MLI) hourly. Alternatively, you can take a bus from Baptist Hospital to Des Moines via Winston Salem, Columbus, S Grant Ave & E Mound St, S High St & E Rich St, Columbus, Chicago Bus Station, and Des Moines in around 26h 50m.

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