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How to get fromWinston-Salem to Knoxvilleby plane, bus, shuttle, or car

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There are 6 ways to get from Winston-Salem to Knoxville by plane, bus, shuttle, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Piedmont Triad International Airport to Mcghee Tyson Airport

    best
    1. Fly from Piedmont Triad International Airport (GSO) to Mcghee Tyson Airport (TYS)plane plane GSO - TYS
    5h 15m
    $174–792

  2. Drive 238.6 mi

    cheapest
    1. Drive from Winston-Salem to Knoxvillecar car 238.6 mi
    4h 53m
    $44–63

  3. Bus, shuttle, drive via Charlotte Airport (CLT)

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Airport to ASU Peacock Hall Boonebus bus
    3. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Knoxvillecar car
    10h 47m
    $341–380

  4. Bus to Charlotte Douglas International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Mcghee Tyson Airport (TYS)plane plane CLT - TYS
    4h 42m
    $156–748

  5. Bus to Charlotte Douglas International Airport, fly to Chattanooga Metropolitan Airport, drive

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Chattanooga Metropolitan Airport (CHA)plane plane CLT - CHA
    3. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    6h 14m
    $134–756

  6. Bus, shuttle, drive

    1. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    2. Take a shuttle bus from Asheville Airport to Black Bear Resortshuttle bus
    3. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    4. Drive from Hot Springs to Chilhowee at Holstoncar car
    11h 39m
    $341–368

Piedmont Triad International Airport (GSO) to Mcghee Tyson Airport (TYS) flights

Calendar110Weekly Planes
Duration4h 41mAverage Duration
Ticket$108Cheapest Price
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Questions & Answers

Map of how to get from Winston-Salem to Knoxville.ExpandLaunch map view
  • Distance: 264 mi
  • Duration: 5h 15m

What companies run services between Winston-Salem, NC, USA and Knoxville, TN, USA?

Delta, American Airlines, and two other airlines fly from Piedmont Triad International Airport (GSO) to Mcghee Tyson Airport (TYS) hourly.

Airlines
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