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How to get fromWinston-Salem to Lexingtonby bus, plane, or car

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There are 9 ways to get from Winston-Salem to Lexington by bus, plane, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Charlotte Douglas International Airport, fly to Louisville International Airport, drive

    best
    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Louisville International Airport (SDF)plane plane CLT - SDF
    3. Drive from Louisville-Airport-SDF to Lexingtoncar car
    5h 58m
    $120–646

  2. Drive  348.9 mi

    cheapest
    1. Drive from Winston-Salem to Lexingtoncar car 348.9 mi
    7h 2m
    $64–92

  3. Bus, drive via Charlotte

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Evansville Bus Stationbus bus
    4. Take the bus from Evansville, IN to Corydon, INbus bus
    5. Drive from Middletown Station @ Target to Lexingtoncar car
    22h 9m
    $215–385

  4. Bus to Charlotte Douglas International Airport, fly to Covington, drive

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Covington (CVG)plane plane CLT - CVG
    3. Drive from Covington (CVG) to Lexingtoncar car
    6h 1m
    $116–647

  5. Fly Piedmont Triad International Airport to Blue Grass Airport

    1. Fly from Piedmont Triad International Airport (GSO) to Blue Grass Airport (LEX)plane plane GSO - LEX
    7h 41m
    $86–444

  6. Bus to Charlotte Douglas International Airport, fly to Blue Grass Airport

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Blue Grass Airport (LEX)plane plane CLT - LEX
    6h 53m
    $68–357

  7. Bus to Charlotte Douglas International Airport, fly to Tri-State Airport, drive

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Tri-State Airport (HTS)plane plane CLT - HTS
    3. Drive from Tri-State Airport (HTS) to Lexingtoncar car
    6h 23m
    $82–390

  8. Bus to Charlotte Douglas International Airport, fly to Mcghee Tyson Airport, drive

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Mcghee Tyson Airport (TYS)plane plane CLT - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Lexingtoncar car
    7h 24m
    $141–775

  9. Bus, drive

    1. Take the bus from Winston Salem(Trans Center) to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Evansville Bus Stationbus bus
    3. Take the bus from Evansville, IN to Corydon, INbus bus
    4. Drive from Middletown Station @ Target to Lexingtoncar car
    22h 19m
    $222–384

Charlotte Douglas International Airport (CLT) to Louisville International Airport (SDF) flights

Calendar61Weekly Planes
Duration2h 9mAverage Duration
Ticket$92Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Winston-Salem to Lexington.ExpandLaunch map view
  • Distance: 500 mi
  • Duration: 5h 58m

What companies run services between Winston-Salem, NC, USA and Lexington, KY, USA?

American Airlines, Delta, and United Airlines fly from Piedmont Triad International Airport (GSO) to Blue Grass Airport (LEX) hourly.

Airlines
Bus operators

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