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How to get fromWinston-Salem to Louisvilleby plane, bus (Greyhound), car, or bus

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There are 7 ways to get from Winston-Salem to Louisville by plane, bus (Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Piedmont Triad International Airport to Louisville International Airport

    best
    1. Fly from Piedmont Triad International Airport (GSO) to Louisville International Airport (SDF)plane plane GSO - SDF
    6h 12m
    $120–676

  2. Bus

    cheapest
    1. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus Charlotte
    2. Take the bus from Columbus - Downtown - Mound St to Louisville, KY Bus Stationbus bus Cleveland
    14h 55m
    $69–151

  3. Bus via Charleston

    1. Take the bus from Winston Salem(Trans Center) to Charleston, WVbus bus
    2. Take the bus from Charleston Bus Station to Wilson & Ferrell Shell Station - Columbusbus bus
    3. Take the bus from N Wilson Rd & Ferrell Pl - Columbus to Louisville, KY Bus Stationbus bus
    14h 15m
    $70–179

  4. Drive 421 mi

    1. Drive from Winston-Salem to Louisvillecar car 421 mi
    8h 8m
    $77–111

  5. Bus to Charlotte Douglas International Airport, fly to Louisville International Airport

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Louisville International Airport (SDF)plane plane CLT - SDF
    5h 44m
    $107–581

  6. Bus to Charlotte Douglas International Airport, fly to Blue Grass Airport, drive

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Blue Grass Airport (LEX)plane plane CLT - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 55m
    $149–847

  7. Bus to Raleigh-Durham International Airport, fly to Louisville International Airport

    1. Take the bus from Winston Salem(Trans Center) to Durhambus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Louisville International Airport (SDF)plane plane RDU - SDF
    7h
    $107–582

Winston-Salem to Louisville by bus

Calendar7Weekly Buses
Duration14h 15mAverage Duration
Ticket$70Cheapest Price
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Questions & Answers

Map of how to get from Winston-Salem to Louisville.ExpandLaunch map view
  • Distance: 380.1 mi
  • Duration: 6h 12m

What companies run services between Winston-Salem, NC, USA and Louisville, KY, USA?

American Airlines, Delta, and two other airlines fly from Piedmont Triad International Airport (GSO) to Louisville International Airport (SDF) hourly. Alternatively, you can take a bus from Winston Salem(Trans Center) to Louisville, KY Bus Station via Charleston Bus Station and N Wilson Rd & Ferrell Pl - Columbus in around 14h 15m.

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