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How to get fromWinston-Salem to Sikestonby bus, plane, taxi, or car

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There are 7 ways to get from Winston-Salem to Sikeston by bus, plane, taxi, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Charlotte Douglas International Airport, fly to Lambert–St. Louis International Airport, bus, taxi

    best
    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL)plane plane CLT - STL
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    4. Take the taxi from Cape Girardeau to Sikestontaxi taxi
    9h 25m
    $226–729

  2. Drive  606.8 mi

    cheapest
    1. Drive from Winston-Salem to Sikestoncar car 606.8 mi
    11h 16m
    $111–160

  3. Bus, drive via Charlotte

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Bus Station to Atlanta Downtownbus bus
    3. Take the bus from Atlanta Bus Station to Paducah Bus Stationbus bus
    4. Drive from Paducah Bus Station to Sikestoncar car
    15h 57m
    $123–190

  4. Bus to Charlotte Douglas International Airport, fly to Nashville, bus, drive

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Nashville (BNA)plane plane CLT - BNA
    3. Take the bus from Nashville Bus Station to Paducah Bus Stationbus bus
    4. Drive from Paducah Bus Station to Sikestoncar car
    9h 58m
    $112–480

  5. Fly Piedmont Triad International Airport to Cape Girardeau Municipal Airport, taxi

    1. Fly from Piedmont Triad International Airport (GSO) to Cape Girardeau Municipal Airport (CGI)plane plane GSO - CGI
    2. Take the taxi from Cape Girardeau Municipal Airport (CGI) to Sikestontaxi taxi
    8h 28m
    $198–672

  6. Bus to Charlotte Douglas International Airport, fly to Memphis, bus

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Memphis (MEM)plane plane CLT - MEM
    3. Take the bus from Tornado Bus Co - West Memphis to Flying J - Matthewsbus bus
    10h 4m
    $224–942

  7. Bus, drive

    1. Take the bus from Winston Salem(Trans Center) to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Paducah Bus Stationbus bus
    3. Drive from Paducah Bus Station to Sikestoncar car
    16h 13m
    $131–195

Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL) flights

Calendar73Weekly Planes
Duration3h 11mAverage Duration
Ticket$95Cheapest Price
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Comparing Your Travel Options

Map of how to get from Winston-Salem to Sikeston.ExpandLaunch map view
  • Distance: 819.1 mi
  • Duration: 9h 25m

What companies run services between Winston-Salem, NC, USA and Sikeston, MO, USA?

There is no direct connection from Winston-Salem to Sikeston. However, you can take the bus to Charlotte Bus Station, walk to Trade St & Graham St, take the line 34 bus to Transit Center- Bay A, walk to Transit Center- Bay V, take the line 5 bus to Charlotte Douglas Airport, walk to Charlotte Douglas International Airport (CLT) airport, fly to Lambert–St. Louis International Airport (STL), walk to LAMBERT AIRPORT TERMINAL #1 station, take the train to CIVIC CENTER station, walk to St Louis Bus Station, take the bus to Cape Girardeau, then take the taxi to Sikeston. Alternatively, you can take a bus from Winston Salem(Trans Center) to Sikeston via Charlotte Bus Station, Atlanta Downtown, Civic Center Station, Garnett Station, Atlanta Bus Station, and Paducah Bus Station in around 15h 57m.

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