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How to get fromWinston-Salem to St. Louisby plane, bus (Greyhound, Flixbus), car, bus, train, or bus (Greyhound)

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There are 7 ways to get from Winston-Salem to St. Louis by plane, bus (Greyhound, Flixbus), car, bus, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Piedmont Triad International Airport

    best
    1. Fly from Piedmont Triad International Airport (GSO) to Lambert–St. Louis International Airport (STL)plane plane GSO - STL
    6h 16m
    $162–776

  2. Drive 679.5 mi

    cheapest
    1. Drive from Winston-Salem to St. Louiscar car 679.5 mi
    12h 23m
    $124–180

  3. Bus

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Bus Station to Atlanta Downtownbus bus
    3. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    18h 19m
    $152–277

  4. Bus to Charlotte Douglas International Airport, fly

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL)plane plane CLT - STL
    5h 49m
    $156–698

  5. Bus to Raleigh-Durham International Airport, fly

    1. Take the bus from Winston Salem(Trans Center) to Durhambus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Lambert–St. Louis International Airport (STL)plane plane RDU - STL
    7h
    $586–1,050

  6. Bus, train

    1. Take the bus from Winston Salem(Trans Center) to Ashlandbus bus
    2. Take the train from Ashland Amtrak Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    19h 11m
    $172–339

  7. Bus via Columbus

    1. Take the bus from Winston Salem to Columbusbus bus Bsb 33
    2. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    20h 35m
    $205–301

Winston-Salem to St. Louis by bus and subway

Calendar4Weekly Services
Duration18h 19mAverage Duration
Ticket$152Cheapest Price
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Questions & Answers

Map of how to get from Winston-Salem to St. Louis.ExpandLaunch map view
  • Distance: 637.6 mi
  • Duration: 6h 16m

What companies run services between Winston-Salem, NC, USA and St. Louis, MO, USA?

American Airlines, Delta, and United Airlines fly from Piedmont Triad International Airport (GSO) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a bus from Winston Salem(Trans Center) to St Louis Bus Station via Charlotte Bus Station, Atlanta Downtown, Civic Center Station, Garnett Station, and Atlanta Bus Station in around 18h 19m.

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