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How to get fromWorcester to Buffalo Depew Stationby bus, plane, train (Amtrak), bus (Greyhound, Flixbus), car, or train

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There are 7 ways to get from Worcester to Buffalo Depew Station by bus, plane, train (Amtrak), bus (Greyhound, Flixbus), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Boston Logan Airport, fly to Buffalo Niagara International Airport

    best
    1. Take the bus from Worcester Union Station to Bostonbus bus
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    4h 12m
    $98–539

  2. Bus

    cheapest
    1. Take the bus from Worcester to Springfieldbus bus Ppb 6713 / ...
    2. Take the bus from Springfield Union Station to Buffalobus bus Greyhound US0171
    12h 33m
    $67–142

  3. Train (Amtrak)

    1. Take the train from Worcester Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    10h 23m
    $140–300

  4. Drive 407 mi

    1. Drive from Worcester to Buffalo Depew Stationcar car 407 mi
    7h 14m
    $75–108

  5. Fly Worcester Regional Airport to Buffalo Niagara International Airport

    1. Fly from Worcester Regional Airport (ORH) to Buffalo Niagara International Airport (BUF)plane plane ORH - BUF
    8h 9m
    $103–566

  6. Bus to Laguardia Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Worcester to New Yorkbus bus
    2. Fly from Laguardia Airport (LGA) to Buffalo Niagara International Airport (BUF)plane plane LGA - BUF
    6h 48m
    $142–711

  7. Bus to Boston Logan Airport, fly to Rochester, train

    1. Take the bus from Worcester Union Station to Bostonbus bus
    2. Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane plane BOS - ROC
    3. Take the train from Rochester to Buffalo Depew Stationtrain train
    6h 15m
    $126–757

Worcester to Buffalo Depew Station by train (Amtrak)

Calendar7Weekly Trains
Duration10h 23mAverage Duration
Ticket$140Cheapest Price
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Questions & Answers

Map of how to get from Worcester to Buffalo Depew Station.ExpandLaunch map view
  • Distance: 441.6 mi
  • Duration: 4h 12m

What companies run services between Worcester, MA, USA and Buffalo Depew Station, NY, USA?

Amtrak operates a train from Worcester Union Station to Buffalo Depew Station once daily. Tickets cost $140–300 and the journey takes 10h 23m. Alternatively, you can take a bus from Worcester to Buffalo Depew Station via Springfield, Springfield Union Station, Ellicott Street & MTC Static, Walden Avenue & Thruway Transit Center, and Walden Avenue & 2929 Walden Avenue in around 12h 33m.

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