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How to get fromWorcester to St. Louisby bus, plane, bus (Greyhound), train (Amtrak), or car

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There are 9 ways to get from Worcester to St. Louis by bus, plane, bus (Greyhound), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Boston Logan Airport, fly

    best
    1. Take the bus from Worcester Union Station to Bostonbus bus
    2. Fly from Boston Logan Airport (BOS) to Lambert–St. Louis International Airport (STL)plane plane BOS - STL
    6h 17m
    $471–919

  2. Fly from Worcester Regional Airport

    cheapest
    1. Fly from Worcester Regional Airport (ORH) to Lambert–St. Louis International Airport (STL)plane plane ORH - STL
    7h 17m
    $125–655

  3. Bus (Greyhound)

    1. Take the bus from Worcester Union Station to Newark Penn Stationbus bus Greyhound US0235 / ...
    2. Take the bus from Newark Penn Station to St Louis Bus Stationbus bus Greyhound US0421
    26h 25m
    $220–329

  4. Train (Amtrak)

    1. Take the train from Worcester Union Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    26h 52m
    $685–1,060

  5. Drive  1,112.7 mi

    1. Drive from Worcester to St. Louiscar car 1,112.7 mi
    19h 45m
    $204–294

  6. Bus to Bradley International Airport, fly

    1. Take the bus from Worcester to Hartfordbus bus
    2. Fly from Bradley International Airport (BDL) to Lambert–St. Louis International Airport (STL)plane plane BDL - STL
    8h 16m
    $148–727

  7. Bus to Theodore Francis Green State Airport, fly

    1. Take the bus from Worcester Union Station to Providencebus bus
    2. Fly from Theodore Francis Green State Airport (PVD) to Lambert–St. Louis International Airport (STL)plane plane PVD - STL
    8h 45m

  8. Bus to Laguardia Airport, fly

    1. Take the bus from Worcester to New Yorkbus bus
    2. Fly from Laguardia Airport (LGA) to Lambert–St. Louis International Airport (STL)plane plane LGA - STL
    8h 41m
    $221–616

  9. Bus to Newark Liberty International Airport, fly

    1. Take the bus from Worcester Union Station to Newark Penn Stationbus bus
    2. Fly from Newark Liberty International Airport (EWR) to Lambert–St. Louis International Airport (STL)plane plane EWR - STL
    8h 39m
    $352–988

Worcester to St. Louis by bus (Greyhound)

Calendar7Weekly Buses
Duration26h 25mAverage Duration
Ticket$220Cheapest Price
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Comparing Your Travel Options

Map of how to get from Worcester to St. Louis.ExpandLaunch map view
  • Distance: 1,102.7 mi
  • Duration: 6h 17m

What companies run services between Worcester, MA, USA and St. Louis, MO, USA?

You can take a bus from Worcester Union Station to St Louis Bus Station via Newark Penn Station in around 26h 25m. Alternatively, you can take a train from Worcester Union Station to St. Louis via Chicago Union Station in around 26h 52m.

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