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How to get fromWytheville to Charlestonby bus (Greyhound), bus, train, car, or plane

Find Transport to Charleston

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There are 6 ways to get from Wytheville to Charleston by bus (Greyhound), bus, train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Wytheville to Charlotte Bus Stationbus bus Columbus
    2. Take the bus from Charlotte Bus Station to Charleston Bus Stationbus bus Greyhound US0643S
    11h 29m
    $80–167

  2. Drive 343 mi

    cheapest
    1. Drive from Wytheville to Charlestoncar car 343 mi
    5h 50m
    $63–91

  3. Bus, train

    1. Take the bus from Max Meadows to Winston Salem(Trans Center)bus bus
    2. Take the bus from Winston Salem(Trans Center) to Greensboro Bus Stopbus bus
    3. Take the train from Greensboro to Selma Stationtrain train
    4. Take the train from Selma Station to Charleston Amtrak Stationtrain train
    12h 8m
    $187–339

  4. Bus to Charlotte Douglas International Airport, fly to Charleston International Airport

    1. Take the bus from Wytheville to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Charleston International Airport (CHS)plane plane CLT - CHS
    6h 53m
    $92–446

  5. Bus to Roanoke Regional Airport-Woodrum Field, fly to Charleston International Airport

    1. Take the bus from Wytheville Rural King Parking Lot to Salem VDOT Park & Ridebus bus
    2. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Charleston International Airport (CHS)plane plane ROA - CHS
    8h 50m
    $76–351

  6. Bus to Charlotte Douglas International Airport, fly to Hilton Head Airport, drive

    1. Take the bus from Wytheville to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Hilton Head Airport (HHH)plane plane CLT - HHH
    3. Drive from Hilton Head Airport (HHH) to Charlestoncar car
    7h 44m
    $108–471

Charlotte Douglas International Airport (CLT) to Charleston International Airport (CHS) flights

Calendar50Weekly Planes
Duration1h 8mAverage Duration
Ticket$51Cheapest Price
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Questions & Answers

Map of how to get from Wytheville to Charleston.ExpandLaunch map view
  • Distance: 438.2 mi
  • Duration: 11h 29m

What companies run services between Wytheville, VA, USA and Charleston, SC, USA?

You can take a vehicle from Wytheville to Transit Mall via Wytheville, Charlotte Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, and Rivers Ave / Cosgrove Ave in around 11h 29m.

Airlines
Train operators
Bus operators

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Need to know: Greyhound

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