There are 7 ways to get from Wytheville to Lancaster by bus, train, car, plane, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, train
best- Take the bus from Wytheville Rural King Parking Lot to Washington Union Stationbus
- Take the train from Washington Union Station to 30th Street Stationtrain
- Take the train from 30th Street Station to Elizabethtown Amtrak Stationtrain
13h 3m$112–205Drive 372.4 mi
cheapest- Drive from Wytheville to Lancastercar 372.4 mi
6h 57m$68–99Bus, train via Roanoke
- Take the bus from Wytheville Rural King Parking Lot to Salem VDOT Park & Ridebus
- Take the train from Roanoke to Washington Union Stationtrain
- Take the train from Washington Union Station to 30th Street Stationtrain
- Take the train from 30th Street Station to Elizabethtown Amtrak Stationtrain
15h 30m$157–328Bus to Charlotte Douglas International Airport, fly to Harrisburg International Airport
- Take the bus from Wytheville to Charlotte Bus Stationbus
- Fly from Charlotte Douglas International Airport (CLT) to Harrisburg International Airport (MDT)plane CLT - MDT
9h 53m$111–518Bus
- Take the bus from Wytheville Rural King Parking Lot to Washington Union Stationbus Highlands Rhythm
- Take the bus from Washington Union Station to Harrisburg Bus Stationbus Greyhound US0430
13h 57m$68–102Bus to Roanoke Regional Airport-Woodrum Field, fly to Philadelphia International Airport, train
- Take the bus from Wytheville Rural King Parking Lot to Salem VDOT Park & Ridebus
- Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Philadelphia International Airport (PHL)plane ROA - PHL
- Take the train from 30th Street Station to Elizabethtown Amtrak Stationtrain
10h 24m$113–502Bus to Piedmont Triad International Airport, fly to Philadelphia International Airport, train
- Take the bus from Max Meadows to Winston Salem(Trans Center)bus
- Fly from Piedmont Triad International Airport (GSO) to Philadelphia International Airport (PHL)plane GSO - PHL
- Take the train from 30th Street Station to Elizabethtown Amtrak Stationtrain
10h 22m$186–752
Wytheville to Lancaster by bus and train
Questions & Answers
The cheapest way to get from Wytheville to Lancaster is to bus which costs $65 - $110 and takes 13h 57m.
The fastest way to get from Wytheville to Lancaster is to drive which takes 6h 57m and costs $65 - $100.
No, there is no direct bus from Wytheville to Lancaster. However, there are services departing from Wytheville Rural King Parking Lot and arriving at W. Chestnut & Water St. via Washington Union Station and AMTRAK ETown. The journey, including transfers, takes approximately 13h 57m.
The distance between Wytheville and Lancaster is 563 miles. The road distance is 374.6 miles.
The best way to get from Wytheville to Lancaster without a car is to bus and train which takes 13h 3m and costs $110 - $210.
It takes approximately 13h 3m to get from Wytheville to Lancaster, including transfers.
Wytheville to Lancaster bus services, operated by Virginia Breeze, depart from Wytheville Rural King Parking Lot station.
Wytheville to Lancaster bus services, operated by Virginia Breeze, arrive at Washington Union Station.
Yes, the driving distance between Wytheville to Lancaster is 375 miles. It takes approximately 6h 57m to drive from Wytheville to Lancaster.
There are 250+ hotels available in Lancaster.
What companies run services between Wytheville, VA, USA and Lancaster, PA, USA?
You can take a bus from Wytheville Rural King Parking Lot to W. Chestnut & Water St. via Washington Union Station, Harrisburg Bus Station, Harrisburg, Elizabethtown Amtrak Station, and AMTRAK ETown in around 13h 57m.
- Website
- aa.com
Flights from Charlotte Douglas International Airport to Harrisburg International Airport
- Ave. Duration
- 1h 43m
- When
- Every day
- Estimated price
- $65–420
Flights from Charlotte Douglas International Airport to Harrisburg International Airport via Philadelphia International Airport
- Ave. Duration
- 3h 48m
- When
- Every day
- Estimated price
- $75–450
Flights from Roanoke Regional Airport-Woodrum Field to Philadelphia International Airport
- Ave. Duration
- 1h 32m
- When
- Every day
- Estimated price
- $60–410
Flights from Piedmont Triad International Airport to Philadelphia International Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- $90–600
Flights from Piedmont Triad International Airport to Philadelphia International Airport via Reagan Washington
- Ave. Duration
- 3h 31m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $90–600
Flights from Piedmont Triad International Airport to Philadelphia International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 3h 48m
- When
- Every day
- Estimated price
- $100–650
- Website
- united.com
Flights from Charlotte Douglas International Airport to Harrisburg International Airport via Washington Dulles
- Ave. Duration
- 3h 35m
- When
- Every day
- Estimated price
- $65–420
Flights from Roanoke Regional Airport-Woodrum Field to Philadelphia International Airport via Washington Dulles
- Ave. Duration
- 3h 47m
- When
- Every day
- Estimated price
- $60–410
Flights from Piedmont Triad International Airport to Philadelphia International Airport via Washington Dulles
- Ave. Duration
- 3h 55m
- When
- Every day
- Estimated price
- $90–600
Rome2Rio's guide to Amtrak Acela
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Washington Union Station to 30th Street Station
- Ave. Duration
- 1h 42m
- Frequency
- Hourly
- Estimated price
- $30–650
- Schedules at
- Amtrak Acela
- Website
- Amtrak
- Business Class
- $30–470
- First Class
- $150–650
Train from Washington Union Station to 30th Street Station
- Ave. Duration
- 1h 42m
- Frequency
- Hourly
- Estimated price
- $30–650
- Schedules at
- Amtrak Acela
- Website
- Amtrak
- Business Class
- $30–470
- First Class
- $150–650
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Washington Union Station to 30th Street Station
- Ave. Duration
- 2h 10m
- Frequency
- Hourly
- Estimated price
- $40–90
- Website
- Amtrak
Train from 30th Street Station to Elizabethtown Amtrak Station
- Ave. Duration
- 1h 32m
- Frequency
- Every 2 hours
- Estimated price
- $26–60
- Website
- Amtrak
Train from Roanoke to Washington Union Station
- Ave. Duration
- 5h 5m
- Frequency
- Twice daily
- Estimated price
- $70–150
- Website
- Amtrak
Train from Washington Union Station to 30th Street Station
- Ave. Duration
- 2h 10m
- Frequency
- Hourly
- Estimated price
- $40–90
- Website
- Amtrak
Train from 30th Street Station to Elizabethtown Amtrak Station
- Ave. Duration
- 1h 32m
- Frequency
- Every 2 hours
- Estimated price
- $26–60
- Website
- Amtrak
Train from 30th Street Station to Elizabethtown Amtrak Station
- Ave. Duration
- 1h 32m
- Frequency
- Every 2 hours
- Estimated price
- $26–60
- Website
- Amtrak
Train from 30th Street Station to Elizabethtown Amtrak Station
- Ave. Duration
- 1h 32m
- Frequency
- Every 2 hours
- Estimated price
- $26–60
- Website
- Amtrak
- Phone
- +1-800-827-3490
- [email protected]
- Website
- Virginia Breeze
Bus from Wytheville Rural King Parking Lot to Washington Union Station
- Ave. Duration
- 6h 35m
- Frequency
- Once daily
- Estimated price
- $45–55
- Schedules at
- Virginia Breeze
Bus from Wytheville Rural King Parking Lot to Salem VDOT Park & Ride
- Ave. Duration
- 1h 35m
- Frequency
- Once daily
- Estimated price
- $20–25
- Schedules at
- Virginia Breeze
Bus from Wytheville Rural King Parking Lot to Washington Union Station
- Ave. Duration
- 6h 35m
- Frequency
- Once daily
- Estimated price
- $45–55
- Schedules at
- Virginia Breeze
Bus from Wytheville Rural King Parking Lot to Salem VDOT Park & Ride
- Ave. Duration
- 1h 35m
- Frequency
- Once daily
- Estimated price
- $20–25
- Schedules at
- Virginia Breeze
- Phone
- +1 888-378-3823
- [email protected]
- Website
- Barons Bus
Bus from Wytheville to Charlotte Bus Station
- Ave. Duration
- 2h 15m
- Frequency
- Once daily
- Estimated price
- $12–50
- Website
- Barons Bus
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Washington Union Station to Harrisburg Bus Station
- Ave. Duration
- 3h 10m
- Frequency
- Once daily
- Estimated price
- $17–35
- Website
- Greyhound
Bus from Max Meadows to Winston Salem(Trans Center)
- Ave. Duration
- 1h 20m
- Frequency
- Once daily
- Estimated price
- $12–23
- Website
- Greyhound
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide












