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How to get fromWytheville to Louisvilleby bus, plane, bus (Greyhound, Amtrak), car, or shuttle

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There are 6 ways to get from Wytheville to Louisville by bus, plane, bus (Greyhound, Amtrak), car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Charlotte Douglas International Airport, fly to Louisville International Airport

    best
    1. Take the bus from Wytheville to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Louisville International Airport (SDF)plane plane CLT - SDF
    6h 49m
    $131–687

  2. Drive 338.6 mi

    cheapest
    1. Drive from Wytheville to Louisvillecar car 338.6 mi
    6h 37m
    $62–90

  3. Bus

    1. Take the bus from Max Meadows to Nashville Bus Stationbus bus Greyhound US0600
    2. Take the bus from Nashville to Louisville, KYbus bus
    11h 29m
    $121–203

  4. Bus to Charlotte Douglas International Airport, fly to Blue Grass Airport, drive

    1. Take the bus from Wytheville to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Blue Grass Airport (LEX)plane plane CLT - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    7h
    $173–903

  5. Bus, shuttle to Tri-Cities Regional Tn/Va Airport, fly to Louisville International Airport

    1. Take the bus from Wytheville Rural King Parking Lot to Bristol Exit 5 Park & Ride Lotbus bus
    2. Take a shuttle bus from Low Gap to Black Bear Resortshuttle bus
    3. Fly from Tri-Cities Regional Tn/Va Airport (TRI) to Louisville International Airport (SDF)plane plane TRI - SDF
    10h 37m
    $301–702

  6. Bus via Columbus

    1. Take the bus from Wytheville to Columbus - Mound Stbus bus Charlotte
    2. Take the bus from Columbus - Downtown - Mound St to Louisville, KY Bus Stationbus bus Cleveland
    13h 24m
    $75–163

Charlotte Douglas International Airport (CLT) to Louisville International Airport (SDF) flights

Calendar35Weekly Planes
Duration1h 32mAverage Duration
Ticket$91Cheapest Price
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Questions & Answers

Map of how to get from Wytheville to Louisville.ExpandLaunch map view
  • Distance: 488.7 mi
  • Duration: 6h 49m

What companies run services between Wytheville, VA, USA and Louisville, KY, USA?

You can take a vehicle from Wytheville to Louisville, KY via Max Meadows and Nashville in around 11h 29m.

Airlines
Bus operators

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