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How to get fromWytheville to St. Louisby bus, plane, bus (Greyhound, Flixbus), car, shuttle, bus (Greyhound), or train

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There are 9 ways to get from Wytheville to St. Louis by bus, plane, bus (Greyhound, Flixbus), car, shuttle, bus (Greyhound), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Charlotte Douglas International Airport, fly

    best
    1. Take the bus from Wytheville to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL)plane plane CLT - STL
    6h 53m
    $163–737

  2. Drive 597.1 mi

    cheapest
    1. Drive from Wytheville to St. Louiscar car 597.1 mi
    10h 52m
    $109–158

  3. Bus via Nashville

    1. Take the bus from Max Meadows to Nashville Bus Stationbus bus Greyhound US0600
    2. Take the bus from Nashville Bus Station to St Louis Bus Stationbus bus Greyhound US0186 / ...
    14h 19m
    $141–258

  4. Bus to Piedmont Triad International Airport, fly

    1. Take the bus from Max Meadows to Winston Salem(Trans Center)bus bus
    2. Fly from Piedmont Triad International Airport (GSO) to Lambert–St. Louis International Airport (STL)plane plane GSO - STL
    8h 18m
    $210–844

  5. Bus, bus to Roanoke Regional Airport-Woodrum Field, fly

    1. Take the bus from Rural King Shopping Center to Route 460 Park and Ridebus bus
    2. Take the bus from Exit 118 - Park and Ride to Airportbus bus
    3. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Lambert–St. Louis International Airport (STL)plane plane ROA - STL
    8h 38m
    $130–643

  6. Bus, shuttle to Tri-Cities Regional Tn/Va Airport, fly

    1. Take the bus from Rural King Shopping Center to Park and Ride Lot at I-81 Exit 5bus bus
    2. Take a shuttle bus from Low Gap to Black Bear Resortshuttle bus
    3. Fly from Tri-Cities Regional Tn/Va Airport (TRI) to Lambert–St. Louis International Airport (STL)plane plane TRI - STL
    10h 35m
    $318–805

  7. Bus, bus to Raleigh-Durham International Airport, fly

    1. Take the bus from Max Meadows to Winston Salem(Trans Center)bus bus
    2. Take the bus from Winston Salem(Trans Center) to Durhambus bus
    3. Fly from Raleigh-Durham International Airport (RDU) to Lambert–St. Louis International Airport (STL)plane plane RDU - STL
    9h 35m
    $617–1,102

  8. Bus

    1. Take the bus from Wytheville to Columbusbus bus Bsb 33
    2. Take the bus from Wilson & Ferrell Shell Station - Columbus to St Louis Bus Stationbus bus Greyhound US0421
    17h 40m

  9. Bus, train

    1. Take the bus from Wytheville to Ashlandbus bus
    2. Take the train from Ashland Amtrak Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    17h 40m
    $163–343

Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL) flights

Calendar56Weekly Planes
Duration2h 58mAverage Duration
Ticket$123Cheapest Price
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Questions & Answers

Map of how to get from Wytheville to St. Louis.ExpandLaunch map view
  • Distance: 734.7 mi
  • Duration: 6h 53m

What companies run services between Wytheville, VA, USA and St. Louis, MO, USA?

You can take a vehicle from Wytheville to St Louis Bus Station via Max Meadows and Nashville Bus Station in around 14h 19m.

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