Rome2Rio

How to get fromWytheville to St. Louisby bus, plane, bus (Greyhound, Flixbus), car, shuttle, bus (Greyhound, Flixbus, Amtrak), or bus (Greyhound)

Find Transport to St. Louis

See all options

There are 9 ways to get from Wytheville to St. Louis by bus, plane, bus (Greyhound, Flixbus), car, shuttle, bus (Greyhound, Flixbus, Amtrak), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Charlotte Douglas International Airport, fly

    best
    1. Take the bus from Wytheville to Charlottebus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL)plane plane CLT - STL
    6h 50m
    $132–636

  2. Drive  597 mi

    cheapest
    1. Drive from Wytheville to St. Louiscar car 597 mi
    10h 57m
    $102–148

  3. Bus

    1. Take the bus from Max Meadows to Nashville Bus Stationbus bus Greyhound US0600
    2. Take the bus from Nashville Bus Station to St Louis Bus Stationbus bus Greyhound US0186 / ...
    14h 29m
    $151–243

  4. Bus to Piedmont Triad International Airport, fly

    1. Take the bus from Max Meadows to Winston Salem(Trans Center)bus bus
    2. Fly from Piedmont Triad International Airport (GSO) to Lambert–St. Louis International Airport (STL)plane plane GSO - STL
    8h 20m
    $167–641

  5. Bus to Roanoke Regional Airport-Woodrum Field, fly

    1. Take the bus from Wytheville Rural King Parking Lot to Salem VDOT Park & Ridebus bus
    2. Fly from Roanoke Regional Airport-Woodrum Field (ROA) to Lambert–St. Louis International Airport (STL)plane plane ROA - STL
    8h 49m
    $129–584

  6. Bus, shuttle to Tri-Cities Regional Tn/Va Airport, fly

    1. Take the bus from Wytheville Rural King Parking Lot to Bristol Exit 5 Park & Ride Lotbus bus
    2. Take a shuttle bus from Low Gap to Black Bear Resortshuttle bus
    3. Fly from Tri-Cities Regional Tn/Va Airport (TRI) to Lambert–St. Louis International Airport (STL)plane plane TRI - STL
    10h 9m
    $325–793

  7. Bus, bus to Raleigh-Durham International Airport, fly

    1. Take the bus from Max Meadows to Winston Salem(Trans Center)bus bus
    2. Take the bus from Winston Salem(Trans Center) to Durhambus bus
    3. Fly from Raleigh-Durham International Airport (RDU) to Lambert–St. Louis International Airport (STL)plane plane RDU - STL
    9h 45m
    $171–696

  8. Bus via Carbondale

    1. Take the bus from Max Meadows to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the bus from Carbondale Intermodal Station to St Louis Bus Stationbus bus
    14h 34m
    $146–226

  9. Bus #2

    1. Take the bus from Wytheville to Columbusbus bus Bsb 33
    2. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    18h 15m
    $128–227

Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL) flights

Calendar75Weekly Planes
Duration3h 7mAverage Duration
Ticket$93Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Wytheville to St. Louis.ExpandLaunch map view
  • Distance: 734.4 mi
  • Duration: 6h 50m

What companies run services between Wytheville, VA, USA and St. Louis, MO, USA?

You can take a vehicle from Wytheville to St Louis Bus Station via Max Meadows and Nashville Bus Station in around 14h 29m.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There