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How to get fromYork to Knoxvilleby plane, train, bus, car, subway, bus (Greyhound, Flixbus), or bus (Flixbus)

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There are 10 ways to get from York to Knoxville by plane, train, bus, car, subway, bus (Greyhound, Flixbus), or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Harrisburg International Airport to Mcghee Tyson Airport

    best
    1. Fly from Harrisburg International Airport (MDT) to Mcghee Tyson Airport (TYS)plane plane MDT - TYS
    6h 41m
    $290–1,379

  2. Drive 529.2 mi

    cheapest
    1. Drive from York to Knoxvillecar car 529.2 mi
    9h 15m
    $97–140

  3. Train, bus

    1. Take the train from Harrisburg to Ny Moynihan Train Hall At Penn Stationtrain train Keystone Service / ...
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    18h 36m
    $202–300

  4. Bus, bus to Ronald Reagan Washington National Airport, fly to Mcghee Tyson Airport

    1. Take the bus from York Bus Stop to Baltimore Downtown Bus Stationbus bus
    2. Take the bus from Baltimore Downtown Bus Station to Washington Union Stationbus bus
    3. Fly from Ronald Reagan Washington National Airport (DCA) to Mcghee Tyson Airport (TYS)plane plane DCA - TYS
    5h 50m
    $242–1,112

  5. Bus to Baltimore-Washington International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from York Bus Stop to Baltimore Downtown Bus Stationbus bus
    2. Fly from Baltimore-Washington International Airport (BWI) to Mcghee Tyson Airport (TYS)plane plane BWI - TYS
    5h 29m
    $185–787

  6. Bus, train, subway to Washington Dulles International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from York Bus Stop to Baltimore Downtown Bus Stationbus bus
    2. Take the train from West Baltimore to New Carrollton Amtrak Stationtrain train
    3. Take the subway from New Carrollton, Orange Line Center Platform to Washington Dulles International Airport, Silver Line Center Platformsubway subway
    4. Fly from Washington Dulles International Airport (IAD) to Mcghee Tyson Airport (TYS)plane plane IAD - TYS
    7h 2m
    $169–699

  7. Train to Philadelphia International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Mcghee Tyson Airport (TYS)plane plane PHL - TYS
    7h 9m
    $252–1,050

  8. Bus, bus to Ronald Reagan Washington National Airport, fly to Asheville Regional Airport, drive

    1. Take the bus from York Bus Stop to Baltimore Downtown Bus Stationbus bus
    2. Take the bus from Baltimore Downtown Bus Station to Washington Union Stationbus bus
    3. Fly from Ronald Reagan Washington National Airport (DCA) to Asheville Regional Airport (AVL)plane plane DCA - AVL
    4. Drive from Asheville-Airport-AVL to Knoxvillecar car
    7h 30m
    $129–627

  9. Bus via Baltimore

    1. Take the bus from York Bus Stop to Baltimore Downtown Bus Stationbus bus
    2. Take the bus from Baltimore Downtown Bus Station to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    22h 42m
    $142–195

  10. Bus

    1. Take the bus from Harrisburg Bus Station to New York City Chinatownbus bus FlixBus N2640
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    23h 15m
    $133–182

Harrisburg International Airport (MDT) to Mcghee Tyson Airport (TYS) flights

Calendar98Weekly Planes
Duration4h 55mAverage Duration
Ticket$233Cheapest Price
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Questions & Answers

Map of how to get from York to Knoxville.ExpandLaunch map view
  • Distance: 543.3 mi
  • Duration: 6h 41m

What companies run services between York, PA, USA and Knoxville, TN, USA?

United Airlines, American Airlines, and two other airlines fly from Harrisburg International Airport (MDT) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from York Bus Stop to Knoxville Station Hall of Fame via Baltimore Downtown Bus Station, New York, NY, Knoxville, TN, Walmart, and Fountain City Superstop in around 22h 42m.

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