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How to get fromYpsilanti to Chicagoby train (Amtrak), bus (Amtrak), car, plane, bus (Greyhound, Flixbus), or bus

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There are 7 ways to get from Ypsilanti to Chicago by train (Amtrak), bus (Amtrak), car, plane, bus (Greyhound, Flixbus), or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Ann Arbor Amtrak Station to Chicago Union Stationtrain train Wolverine
    4h 31m
    $105–196

  2. Bus via Chicago Bus Station

    cheapest
    1. Take the bus from Ann Arbor to Chicago Bus Stationbus bus Greyhound US0160
    7h 22m
    $38–78

  3. Bus (Amtrak)

    1. Take the bus from Ann Arbor Amtrak Station to Chicago Union Stationbus bus Amtrak Thruway Connecting Service
    7h 1m
    $88–124

  4. Drive 249.1 mi

    1. Drive from Ypsilanti to Chicagocar car 249.1 mi
    4h 9m
    $46–66

  5. Drive to Capital Region International Airport, fly to Chicago O'Hare International Airport

    1. Drive from Ypsilanti to Lansing-Airport-LANcar car
    2. Fly from Capital Region International Airport (LAN) to Chicago O'Hare International Airport (ORD)plane plane LAN - ORD
    3h 19m
    $56–315

  6. Line 4 bus, bus to Detroit, fly to Chicago Midway International Airport

    1. Take the bus from YTC - Stop 2 to Blake Transit Centerbus bus
    2. Take the bus from Ann Arbor- Blake Transit Ctr., MI to Detroit Metro Airportbus bus
    3. Fly from Detroit (DTW) to Chicago Midway International Airport (MDW)plane plane DTW - MDW
    5h 16m
    $140–484

  7. Line 4 bus, bus to Detroit, fly to Chicago O'Hare International Airport

    1. Take the bus from YTC - Stop 2 to Blake Transit Centerbus bus
    2. Take the bus from Ann Arbor- Blake Transit Ctr., MI to Detroit Metro Airportbus bus
    3. Fly from Detroit (DTW) to Chicago O'Hare International Airport (ORD)plane plane DTW - ORD
    5h 34m
    $160–674

Ypsilanti to Chicago by bus (Amtrak)

Calendar1Weekly Buses
Duration7h 1mAverage Duration
Ticket$88Cheapest Price
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Questions & Answers

Map of how to get from Ypsilanti to Chicago.ExpandLaunch map view
  • Distance: 250.7 mi
  • Duration: 4h 31m

What companies run services between Ypsilanti, MI, USA and Chicago, IL, USA?

Amtrak operates a train from Ann Arbor Amtrak Station to Chicago Union Station 3 times a day. Tickets cost $75–160 and the journey takes 4h 18m. Alternatively, Amtrak operates a bus from Ann Arbor Amtrak Station to Chicago Union Station once a week. Tickets cost $85–120 and the journey takes 4h 39m.

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