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How to get fromAntigua Guatemala to Panama Cityby bus, plane, car, or shuttle

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There are 7 ways to get from Antigua Guatemala to Panama City by bus, plane, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to La Aurora International Airport, fly to Tocumen International Airport

    best
    1. Take the bus from Antigua Guatemala to Terminal de Autobusesbus bus
    2. Fly from La Aurora International Airport (GUA) to Tocumen International Airport (PTY)plane plane GUA - PTY
    6h 55m
    $230–440

  2. Bus

    cheapest
    1. Take the bus from Guatemala Estación Zona 10 to Terminal San Carlos - Ticabusbus bus
    2. Take the bus from Terminal Tica Bus San Salvador to Terminal Tica Bus San Josébus bus
    3. Take the bus from Terminal Tica Bus to Terminal Albrookbus bus
    2d 2h
    $160–233

  3. Bus via Escuintla

    1. Take the bus from Escuintla to San Salvadorbus bus
    2. Take the bus from Terminal San Carlos - CCA to Terminal Atlántico Nortebus bus Sac
    3. Take the bus from Terminal Tica Bus San José to Terminal Tica Bus Panamábus bus
    44h 30m

  4. Drive 1,883.1 km

    1. Drive from Antigua Guatemala to Panama Citycar car 1,883.1 km
    28h 39m
    $258–373

  5. Shuttle to Cuscatlán International Airport, fly to Tocumen International Airport

    1. Take a shuttle bus from Antigua Guatemala to San Salvadorshuttle bus
    2. Fly from Cuscatlán International Airport (SAL) to Tocumen International Airport (PTY)plane plane SAL - PTY
    10h 41m
    $478–688

  6. Fly La Aurora International Airport to Panama Pacific International Airport

    1. Fly from La Aurora International Airport (GUA) to Panama Pacific International Airport (BLB)plane plane GUA - BLB
    12h 44m
    $189–413

  7. Shuttle, bus

    1. Take a shuttle bus from Antigua Guatemala to San Salvadorshuttle bus
    2. Take the bus from San Salvador to San Josébus bus
    3. Take the bus from San José to Paso Canoasbus bus
    4. Take the bus from Frontera to Albrook - Panamabus bus
    45h 53m
    $250–257

La Aurora International Airport (GUA) to Tocumen International Airport (PTY) flights

Calendar64Weekly Planes
Duration3h 20mAverage Duration
Ticket$73Cheapest Price
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Questions & Answers

Map of how to get from Antigua Guatemala to Panama City.ExpandLaunch map view
  • Distance: 1,423.4 km
  • Duration: 6h 55m

What companies run services between Antigua Guatemala and Panama City, Panama?

You can take a bus from Antigua Guatemala to Terminal Tica Bus Panamá via Escuintla, Escuintla, San Salvador, Terminal San Carlos - CCA, Terminal Atlántico Norte, and Terminal Tica Bus San José in around 44h 30m. Alternatively, AeroRepública flies from La Aurora International Airport (GUA) to Panama Pacific International Airport (BLB) 3 times a week.

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