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How to get fromSanta Fe to Panama Cityby bus, car, taxi, or plane

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There are 6 ways to get from Santa Fe to Panama City by bus, car, taxi, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Santa Fé to Santiagobus bus
    2. Take the bus from Santiago to Gran Terminal Nacional de Transportebus bus David
    4h 43m
    $12–20

  2. Drive 287.7 km

    1. Drive from Santa Fe to Panama Citycar car 287.7 km
    4h 49m
    $40–57

  3. Bus, taxi to Lago Bay, fly to Albrook Airport

    1. Take the bus from Santa Fé to Santiagobus bus
    2. Take the taxi from Santiago to Lago Baytaxi taxi
    3. Fly from Lago Bay to Albrook Airportplane plane
    3h 31m
    $858–2,273

  4. Bus via Penonomé

    1. Take the bus from Santa Fé to Santiagobus bus
    2. Take the bus from Santiago de Veraguas to Penonomébus bus
    3. Take the bus from Penonomé to Gran Terminal Nacional de Transportebus bus
    5h 37m
    $21–30

  5. Bus via Lídice

    1. Take the bus from Santa Fé to Santiagobus bus
    2. Take the bus from Santiago to Capirabus bus
    3. Take the bus from Capira to Gran Terminal Nacional de Transportebus bus
    7h

  6. Bus, bus to Chitre, fly to Albrook Marcos A. Gelabert International Airport

    1. Take the bus from Santa Fé to Santiagobus bus
    2. Take the bus from Santiago to Ocubus bus
    3. Take the bus from Ocu to Chitrébus bus
    4. Fly from Chitre (CTD) to Albrook Marcos A. Gelabert International Airport (PAC)plane plane CTD - PAC
    5h 5m
    $150–157

Lago Bay to Albrook Airport flights

Calendar14Weekly Planes
Duration45 minAverage Duration
Ticket$840Cheapest Price
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Questions & Answers

Map of how to get from Santa Fe to Panama City.ExpandLaunch map view
  • Distance: 303.8 km
  • Duration: 4h 43m

What companies run services between Santa Fe, Veraguas, Panama and Panama City, Panama?

You can take a bus from Santa Fé to Gran Terminal Nacional de Transporte via Santiago in around 4h 43m.

Airlines
Bus operators
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Want to know more about travelling around the world?

Rome2Rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including How to get from Stansted Airport into central London, Need to know: Eurostar, and The London Underground: Essential tips to navigate the Tube - to help you get the most out of your next trip.