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How to get fromSantiago de Cuba to Panama Cityby plane or bus

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There are 4 ways to get from Santiago de Cuba to Panama City by plane or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Antonio Maceo International Airport to Tocumen International Airport

    best
    1. Fly from Antonio Maceo International Airport (SCU) to Tocumen International Airport (PTY)plane plane SCU - PTY
    9h 5m
    $152–592

  2. Fly Antonio Maceo International Airport to Panama Pacific International Airport

    1. Fly from Antonio Maceo International Airport (SCU) to Panama Pacific International Airport (BLB)plane plane SCU - BLB
    16h 31m
    $201–505

  3. Bus to Frank País International Airport, fly to Panama Pacific International Airport

    1. Take the bus from Terminal de Ómnibus Nacionales Santiago de Cuba to Holguin Airportbus bus
    2. Fly from Frank País International Airport (HOG) to Panama Pacific International Airport (BLB)plane plane HOG - BLB
    27h 19m
    $193–464

  4. Bus to Frank País International Airport, fly to Tocumen International Airport

    1. Take the bus from Terminal de Ómnibus Nacionales Santiago de Cuba to Holguin Airportbus bus
    2. Fly from Frank País International Airport (HOG) to Tocumen International Airport (PTY)plane plane HOG - PTY
    12h 50m
    $164–611

Antonio Maceo International Airport (SCU) to Tocumen International Airport (PTY) flights

Calendar7Weekly Planes
Duration6h 43mAverage Duration
Ticket$115Cheapest Price
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Questions & Answers

Map of how to get from Santiago de Cuba to Panama City.ExpandLaunch map view
  • Distance: 1,303.6 km
  • Duration: 9h 5m

What companies run services between Santiago de Cuba and Panama City, Panama?

American Airlines, Copa Airlines, and two other airlines fly from Antonio Maceo International Airport (SCU) to Tocumen International Airport (PTY) once daily.

Airlines
Bus operators

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